HCID 66808398, compound → HCID 60204790, compound

HRID 605165Notes

Reaction equation

HRID 605165 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12]([NH:13][C:14]3[CH:19]=[C:18]([N+:20]([O-])=O)[CH:17]=[CH:16][C:15]=3[S:23][C:24]3[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=3)=[N:11][CH:10]=[N:9][C:8]=2[N:31]=1)([CH3:3])[CH3:2]>C(O)(=O)C.CO.[Pd]>[NH2:20][C:18]1[CH:17]=[CH:16][C:15]([S:23][C:24]2[CH:25]=[CH:26][C:27]([OH:30])=[CH:28][CH:29]=2)=[C:14]([NH:13][C:12]2[C:7]3[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[N:31][C:8]=3[N:9]=[CH:10][N:11]=2)[CH:19]=1

Participants

5

Reactant 1

HCID 66808398HCID 66808398, compound

Product 1

HCID 60204790HCID 60204790, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

A slurry of 4-[2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-nitro-phenylsulfanyl]-phenol (0.7 g, 1.73 mmol) and 10% Pd/C (100 mg) in acetic acid (10 ml) and methanol (10 mL) was placed under a hydrogen balloon atmosphere with stirring for 20 hours at room temperature. The slurry was filtered and the solvent removed under vacuum to provide 4-[4-Amino-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol as an acetic acid salt

Workup

  1. filtrationThe slurry was filtered
  2. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-eeb2c0c4648e4f0fbfadfae3b892350e
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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