反应详情

The product from Example 137B was reacted with o-anisidine according to the procedure from Example 137C substituting o-anisidine for 5-amino-o-cresol to provide the title compound as an off white solid after silica gel chromatography (120 mg, 67%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.34 (d, J=6.99 Hz, 6H), 3.12-3.28 (m, 1H), 3.78 (s, 3H), 3.81 (s, 3H), 6.92-7.05 (m, 4H), 7.05-7.12 (m, 1H), 7.13-7.23 (m, 1H), 7.40 (d, J=8.82 Hz, 2H), 7.64 (d, J=8.46 Hz, 1H), 7.71 (d, J=7.72 Hz, 1H), 7.81 (d, J=8.82 Hz, 1H), 7.99 (s, 1H), 8.59 (s, 1H), 8.86 (d, J=8.46 Hz, 1H), 9.44 (s, 1H), 9.44 (s, 1H); MS (APCI) m/z 553 (M+H)+.