O-Toluidine → HCID 67040919, compound

Participants

Reaction Steps

The product from Example 137B was reacted with o-toluidine according to the procedure from Example 137C substituting o-toluidine for 5-amino-o-cresol to provide the title compound as an off white solid after silica gel chromatography (74 mg, 92%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.34 (d, J=6.99 Hz, 6H), 2.34 (s, 3H), 3.18-3.29 (m, 1H), 3.78 (s, 3H), 6.91 (d, J=7.35 Hz, 1H), 7.00 (d, J=8.09 Hz, 2H), 7.22 (t, J=7.72 Hz, 1H), 7.40 (d, J=8.46 Hz, 2H), 7.50-7.72 (m, 4H), 7.81 (d, J=8.09 Hz, 1H), 8.00 (s, 1H), 8.59 (s, 1H), 8.87 (d, J=8.46 Hz, 1H), 10.13 (s, 1H), 10.21 (s, 1H); MS (APCI) m/z 536 (M+H)+.

Provenance & Evidence