N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine → 4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol

Participants

Role	Name	HCID	Charge
Reactant	N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808319	—
Reactant	4-[2-Amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol	HCID 66808677	—
Reactant	3-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol	HCID 67040301	—
Product	4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol	HCID 67040784	35.4%

Reaction Steps

The product of Example 153B (380 mg, 1.63 mmol) was reacted with the product of Example 29A (284 mg, 1.63 mmol) using the procedure of Example 29E substituting the product of Example 153B for the product of Example 29D to provide a solid which was triturated with methanol to provide the title compound (209 mg, 35%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07910595B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-efc23e559d5d4fcfa8ede741eae2a5a9
Source note	uspto-grants-2011_03