Ethanol → HCID 67040841, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 154A (307 mg, 0.463 mmol), ammonium chloride (162 mg, 3.03 mmol), and iron powder (159 mg, 2.845 mmol) in a mixture of water (3 mL), ethanol (6 mL) and tetrahydrofuran (6 mL) was heated at 90° C. under a nitrogen atmosphere for 1 hour. The reaction was cooled to room temperature, diluted with ethyl acetate (100 mL), and washed with water (3×50 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated by rotary evaporation in vacuo to give the product as a light yellow solid (224 mg, 76

Provenance & Evidence