HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 605200Generated: October 30, 2026
Thionyl Chloride → 4-Fluoro-3-nitrobenzoyl chloride
https://huagongshe.com/reaction/605200
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluoro-3-nitrobenzoic acid | HCID 67987 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 4-Fluoro-3-nitrobenzoyl chloride | HCID 2783347 | — |
Reaction Steps
The title compound was prepared from 4-Fluoro-3-nitro-benzoic acid (1.00 g, 5.40 mmol) dissolved in dichloroethane (25 mL) to which was added SOCl2 (6.427 g, 54.02 mmol). This mixture was heated to 80° C. for 12 h at which point all the solvent was removed on under vacuum and the crude oil was taken forward without purification (1.10 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07910595B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-96fa4cf8909a451f91068001a51afe7a |
|---|
| Source note | uspto-grants-2011_03 |
|---|
