HCID 67040322, compound → HCID 67040920, compound

Participants

Reaction Steps

The product from Example 172e was dissolved in a 1:1 mixture of TFA in DCM and stirred at room temperature for 2 hrs. The solvent was removed under vacuum and the crude oil was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (85 mg, 36%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.75 (d, J=6.99 Hz, 6 H), 7.21 (d, J=8.09 Hz, 2 H), 7.29-7.35 (m, 2 H), 7.38 (d, J=8.82 Hz, 1 H), 8.14 (d, J=8.82 Hz, 2 H), 8.25 (d, J=8.46 Hz, 1 H), 8.40 (d, J=8.46 Hz, 3 H), 8.56 (d, J=1.84 Hz, 1 H), 9.26 (s, 1 H), 9.37 (d, J=8.82 Hz, 1 H), 10.98 (s, 1 H); MS (ESI+) m/z 559 (M+TFA+H)+; (ESI−) m/z 557 (M+TFA−H)−.

Provenance & Evidence