HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(1R)-1-chloroethyl]-3-(methylsulfonyl)benzene → (2R)-2-{[2-Amino-5-({(1S)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]-amino}-4-methylpentan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(1R)-1-chloroethyl]-3-(methylsulfonyl)benzene | HCID 66622713 | — |
| Reactant | HCID 178445911 | HCID 178445911 | — |
| Product | (2R)-2-{[2-Amino-5-({(1S)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]-amino}-4-methylpentan-1-ol | HCID 11964579 | — |
Reaction Steps
The title compound was prepared from (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol (16.5 g, 55.3 mmol) and 1-[(1R)-1-chloroethyl]-3-(methylsulfonyl)benzene (12.1 g, 55.3 mmol) according to general method A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440992B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-130492fc759249a48e39d6f8cc38a098 |
| Source note | uspto-grants-2016_09 |