Ethanol → HCID 67040267, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 201A (200 mg, 0.3233 mmol), ammonium chloride (113 mg, 2.118 mmol), and iron powder (111 mg, 1.988 mmol) in a mixture of water (3 mL), ethanol (6 mL) and tetrahydrofuran (6 mL) was heated at 80° C. under a nitrogen atmosphere for 75 minutes. The reaction was cooled to room temperature, diluted with ethyl acetate (100 mL), and washed with water (2×50 mL) and brine (50 mL). The organic was dried over anhydrous sodium sulfate, filtered, and concentrated by rotary evaporation in vacuo to give the product as a light beige solid (175 mg, 92%).

Provenance & Evidence