Cesium carbonate → HCID 86615559, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the product of Example 202A (300 mg, 0.8274 mmol) in anhydrous N,N-dimethylformamide (8 mL) was treated with 4-mercaptophenol (104.4 mg, 0.8274 mmol) and cesium carbonate (539 mg, 1.655 mmol) at room temperature, then heated at 100° C. under a nitrogen atmosphere for 2 hours. The reaction was cooled to room temperature and the solvent removed by rotary evaporation in vacuo. The residue was taken up in water (50 mL) and the pH adjusted to 3 with 1N aqueous HCl. The aqueous was extracted with ethyl acetate (100 mL), and the organic extract washed with water (2×25 mL) and brine (25 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated by rotary evaporation to give the product as a golden-brown solid (416 mg, 111%).

Provenance & Evidence