Ethanol → HCID 67041003, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 224D (174 mg, 0.2868 mmol), ammonium chloride (100.5 mg, 1.879 mmol), and iron powder (98.5 mg, 1.764 mmol) in a mixture of water (3 mL), ethanol (6 mL) and tetrahydrofuran (6 mL) was heated at 80° C. under a nitrogen atmosphere for 1 hour. The reaction was cooled to room temperature, diluted with ethyl acetate (100 mL), and washed with water (2×25 mL) and brine (25 mL). The organic was dried over anhydrous sodium sulfate, filtered, and concentrated by rotary evaporation in vacuo to give the product as a yellow solid (160 mg, 97%).

Provenance & Evidence