HCID 67040437, compound → HCID 67040585, compound

Participants

Reaction Steps

The product from Example 225d (212 mg, 0.323 mmol) was dissolved in a 1:1 mixture of TFA in CH2Cl2 and stirred at room temperature for 2 hrs. The solvent was removed under vacuum and the crude oil was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (9 mg, 5%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.34 (d, J=6.99 Hz, 6 H), 1.42 (s, 9 H), 3.21-3.36 (m, 1 H), 6.79-6.87 (m, 2 H), 6.94 (d, J=8.82 Hz, 3 H), 7.86 (d, J=8.46 Hz, 1 H), 8.15 (dd, J=8.82, 2.21 Hz, 1 H), 8.28 (d, J=2.21 Hz, 1 H), 8.88 (s, 1 H), 8.99 (d, J=8.46 Hz, 1 H); MS (ESI+) m/z 555 (M+TFA+H)+; (ESI−) m/z 553 (M+TFA−H)−.

Provenance & Evidence