HCID 67040317, compound → HCID 67040441, compound

Participants

Reaction Steps

The product from Example 227d (366 mg, 0.555 mmol) was dissolved in a 1:1 mixture of TFA in CH2Cl2 and stirred at room temperature for 2 hrs. The solvent was removed under vacuum and the crude oil was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (47 mg, 15%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.35 (d, J=6.99 Hz, 6 H), 3.29 (dt, J=13.70, 6.94 Hz, 1 H), 6.86-7.00 (m, 5 H), 7.88 (d, J=8.46 Hz, 1 H), 8.11 (dd, J=8.64, 2.39 Hz, 1 H), 8.21-8.30 (m, 2 H), 8.40 (d, J=8.82 Hz, 1 H), 8.79 (s, 1 H), 8.90 (s, 1 H), 9.00 (d, J=8.46 Hz, 1 H), 11.28 (s, 1 H); MS (ESI+) m/z 560 (M+TFA+H)+; (ESI−) m/z 558 (M+TFA−H)−.

Provenance & Evidence