Water → HCID 67040679, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 238b (2.5 g, 8.5 mmol) in DMF (50 mL) was added CsCO3 (5.5 g, 17.0 mmol), and 4-aminothiophenol (1.0 g, 8.5 mmol). The mixture was heated at 80° C. for 16 h. The reaction was cooled and poured into water. The aqueous phase was extracted with ethyl acetate (2×). The combined organic phases were washed with water, brine, and dried over sodium sulfate, filtered and concentrated under vacuum giving the title compound. The residue was purified by silica gel chromatography eluting with hexanes/ethyl acetate/methanol (60:30:10) to give the desired product (1.5 g, 46%).

Provenance & Evidence