Potassium Carbonate → Thiophene-2-carboxylic acid [4-(4-hydroxy-phenylsulfanyl)-3-nitro-phenyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	4-Mercaptophenol	HCID 240147	—
Reactant	N-(4-fluoro-3-nitrophenyl)thiophene-2-carboxamide	HCID 771974	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	Thiophene-2-carboxylic acid [4-(4-hydroxy-phenylsulfanyl)-3-nitro-phenyl]-amide	HCID 67040141	79.2%

Reaction Conditions

Temperature	80 °C

Reaction Steps

The product of Example 240a (1.50 g, 5.63 mmol) was dissolved in DMF to which K2CO3 (1.55 g, 11.27 mmol), and 4-mercapto-phenol (711 mg, 5.634 mmol) were added. The reaction mixture was then heated to 80° C. for 2 hrs. At this point the reaction mixture was cooled to room temperature and diluted with water which was then extracted with ethyl acetate to isolate the desired compound (1.66 g, 79%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07910595B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-b46682478ecc4bb4998f7aad4c465cc0
Source note	uspto-grants-2011_03