Methanol → HCID 67040286, compound

Participants

Reaction Steps

The product from Example 247b (1.18 g, 2.27 mmol), iron powder (0.51 g, 9.1 mmol) and ammonium chloride (0.14 g, 2.5 mmol) in a methanol (10 ml), THF (10 ml) and water (5 mL) solution was heated at reflux for 1.5 hr. The resultant mixture was filtered, rinsed with hot methanol (50 ml) and concentrated under vacuum to an oily residue. The residue was diluted with ethyl acetate (100 ml) and washed with water and 10% sodium chloride, then dried over anhydrous sodium sulfate. The drying agent was filtered and the organic solvent was removed under vacuum providing the title compound (0.81 g, 73%).

Provenance & Evidence