HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzonitrile → HCID 67040913, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | 5-Amino-2-methylphenol | HCID 17818 | — |
| Reactant | 3-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride | HCID 86615550 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67040913 | HCID 67040913 | — |
Reaction Steps
The product from Example 137B was reacted with 4-aminobenzonitrile according to the procedure from Example 137C substituting 4-aminobenzyonitrile for 5-amino-o-cresol to provide the title compound as an off white solid after trituration of the reaction product from methanol (20 mg, 23%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 10.63 (s, 1 H), 8.92 (s, 1 H), 8.69 (s, 1 H), 7.96 (d, J=8.82 Hz, 2 H), 7.66-7.90 (m, 4 H), 7.35-7.46 (m, 3 H), 6.95-7.11 (m, 3 H), 6.55-6.64 (m, 1 H), 3.77 (s, 3 H), 3.18-3.30 (m, 1 H), 1.35 (d, J=6.99 Hz, 6 H); MS (ESI+) m/z 547.3 (M+H)+, (ESI−) m/z 545.3 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07910595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-b054efb8c4a34111a4bc1751e115004a |
| Source note | uspto-grants-2011_03 |