3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester → 4-(4-Methoxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

HRID 605280Notes

Reaction equation

HRID 605280 reaction equation
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH2:19])[CH:5]=1.C([C:23]1[C:24]([N:29]=[CH:30][N:31]([CH3:33])C)=[N:25][CH:26]=[CH:27][CH:28]=1)#N>>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH:19][C:33]2[C:23]3[CH:28]=[CH:27][CH:26]=[N:25][C:24]=3[N:29]=[CH:30][N:31]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 613055833-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl esterHCID 66808319N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine2×

Product 1

HCID 670406454-(4-Methoxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

Procedure

The product from Example 136B and the product from Example 29A were reacted according to the procedure from Example 136C substituting the product from Example 29A for the product from Example 8E to provide the title compound.

Sources & evidence

ORD record
ord-63966feeb0d145779c953a9d7fbbe186
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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