反应详情

The product from Example 260C was reacted according to the procedure from Example 150 substituting the product from Example 260C for the product from Example 138 to provide a residue which was purified by trituration from methanol to provide the title compound as an off white solid (33.3 mg, 90%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 11.74 (s, 1 H), 10.54 (s, 1 H), 10.01 (s, 1 H), 9.19 (s, 1 H), 9.11 (d, J=7.35 Hz, 1 H), 8.90 (s, 1 H), 8.19 (s, 1 H), 7.86-8.08 (m, 4 H), 7.60 (t, J=7.91 Hz, 1 H), 7.46 (d, J=7.72 Hz, 1 H), 7.24-7.38 (m, 2 H), 7.03 (d, J=8.46 Hz, 1 H), 6.73-6.91 (m, 2 H); MS (ESI+) m/z 534.1 (M+H)+, (ESI−) m/z 532.2 (M−H)−.

1. customto provide a residue which
2. customwas purified by trituration from methanol