3-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-N-p-tolyl-benzamide → N-(4-Fluoro-3-methyl-phenyl)-4-(4-hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Participants

Reaction Steps

The product from Example 261A was reacted according to the procedure from Example 150 substituting the product from Example 261A for the product from Example 138 to provide a residue which was purified by trituration from methanol to provide the title compound as an off white solid (30.4 mg, 82%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 10.22 (s, 1 H), 10.01 (s, 1 H), 9.20 (d, J=3.68 Hz, 1 H), 9.12 (d, J=8.82 Hz, 1 H), 8.92 (s, 1 H), 7.83-8.00 (m, 4 H), 7.64 (dd, J=7.17, 2.39 Hz, 1 H), 7.50-7.60 (m, 1 H), 7.29-7.34 (m, 2 H), 7.12 (t, J=9.19 Hz, 1 H), 7.02 (d, J=8.46 Hz, 1 H), 6.80-6.85 (m, 2 H), 2.23 (d, J=1.84 Hz, 3 H); MS (ESI+) m/z 498.1 (M+H)+, (ESI−) m/z 496.1 (M−H)−.

Provenance & Evidence