4-Fluoro-3-nitroaniline → HCID 4446960, compound

HRID 605300Notes

Reaction equation

HRID 605300 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16](Cl)=[O:17].S1C=CC=C1C(Cl)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:16](=[O:17])[C:15]2[CH:19]=[CH:20][CH:21]=[C:13]([CH3:12])[CH:14]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

4

Reactant 3

HCID 677684-Fluoro-3-nitroanilineHCID 743753-Methylbenzoyl chlorideHCID 789282-Thiophenecarbonyl chloride

Product 1

HCID 4446960HCID 4446960, compound

Procedure

4-Fluoro-3-nitro-phenylamine was reacted with 3-methylbenzoyl chloride according to the procedure of Example 256a substituting 3-methylbenzoyl chloride for thiophene-2-carbonyl chloride to provide N-(4-Fluoro-3-nitro-phenyl)-3-methyl-benzamide which was then reacted according to the procedures of Examples 256b and 256c to provide the title product.

Sources & evidence

ORD record
ord-e01fec5df3de46aba6b232388cdbac19
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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