p-Anisoyl chloride → HCID 737722, compound

HRID 605301Notes

Reaction equation

HRID 605301 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][O:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=1.S1C=CC=C1C(Cl)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:18](=[O:19])[C:17]2[CH:21]=[CH:22][C:14]([O:13][CH3:12])=[CH:15][CH:16]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

4

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 677684-Fluoro-3-nitroanilineHCID 789282-Thiophenecarbonyl chloride

Product 1

HCID 737722HCID 737722, compound

Procedure

4-Fluoro-3-nitro-phenylamine was reacted with 4-methoxybenzoyl chloride according to the procedure of Example 256a substituting 4-methoxybenzoyl chloride for thiophene-2-carbonyl chloride to provide N-(4-Fluoro-3-nitro-phenyl)-4-methoxy-benzamide which was then reacted according to the procedures of Examples 256b and 256c to provide the title product.

Sources & evidence

ORD record
ord-9d362f2f22ac4a389c2b9c9b545f74e4
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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