4-Fluoro-3-nitroaniline → HCID 776297, compound

HRID 605302Notes

Reaction equation

HRID 605302 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17](Cl)=[O:18].S1C=CC=C1C(Cl)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:17](=[O:18])[C:16]2[CH:20]=[CH:21][CH:22]=[C:14]([O:13][CH3:12])[CH:15]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

4

Reactant 3

HCID 677684-Fluoro-3-nitroanilineHCID 74374m-Anisoyl chlorideHCID 789282-Thiophenecarbonyl chloride

Product 1

HCID 776297HCID 776297, compound

Procedure

4-Fluoro-3-nitro-phenylamine was reacted with 3-methoxybenzoyl chloride according to the procedure of Example 256a substituting 3-methoxybenzoyl chloride for thiophene-2-carbonyl chloride to provide N-(4-Fluoro-3-nitro-phenyl)-3-methoxy-benzamide which was then reacted according to the procedures of Examples 256b and 256c to provide the title product.

Sources & evidence

ORD record
ord-7e641c2902f24bfd8bfbc9f9b6f5e74f
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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