4-Fluoro-3-nitroaniline → HCID 25519222, compound

HRID 605303Notes

Reaction equation

HRID 605303 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[F:12][C:13]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:14]=1[C:15](Cl)=[O:16].S1C=CC=C1C(Cl)=O>>[F:12][C:13]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:14]=1[C:15]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)=[O:16]

Participants

4

Reactant 3

HCID 677684-Fluoro-3-nitroanilineHCID 789282-Thiophenecarbonyl chlorideHCID 5880822,5-Difluorobenzoyl chloride

Product 1

HCID 25519222HCID 25519222, compound

Procedure

4-Fluoro-3-nitro-phenylamine was reacted with 2,5-difluorobenzoyl chloride according to the procedure of Example 256a substituting 2,5-difluorobenzoyl chloride for thiophene-2-carbonyl chloride to provide 2,5-Difluoro-N-(4-fluoro-3-nitro-phenyl)-benzamide which was then reacted according to the procedures of Examples 256b and 256c to provide the title product.

Sources & evidence

ORD record
ord-d98ba1847e5c4ea68002069b9e42cf01
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

Loading…