4-Fluoro-3-nitroaniline → HCID 28081193, compound

HRID 605305Notes

Reaction equation

HRID 605305 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[F:12][C:13]([F:28])([F:27])[C:14]1[CH:15]=[C:16]([CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:17](Cl)=[O:18].S1C=CC=C1C(Cl)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:17](=[O:18])[C:16]2[CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=[C:14]([C:13]([F:12])([F:27])[F:28])[CH:15]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

4

Reactant 3

HCID 677684-Fluoro-3-nitroanilineHCID 789282-Thiophenecarbonyl chlorideHCID 1018563,5-Bis(trifluoromethyl)benzoyl chloride

Product 1

HCID 28081193HCID 28081193, compound

Procedure

4-Fluoro-3-nitro-phenylamine was reacted with 3,5-bis-trifluoromethyl-benzoyl chloride according to the procedure of Example 256a substituting 3,5-bis-trifluoromethyl-benzoyl chloride for thiophene-2-carbonyl chloride to provide N-(4-Fluoro-3-nitro-phenyl)-3,5-bis-trifluoromethyl-benzamide which was then reacted according to the procedures of Examples 256b and 256c to provide the title product.

Sources & evidence

ORD record
ord-a5a159956c874cf482d095e84672566e
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

Loading…