Potassium Carbonate → HCID 67040824, compound

Participants

Reaction Conditions

Reaction Steps

To a flask equipped with a magnetic stir bar and vigreux column was added the product from Example 349A, 4-mercaptophenol, potassium carbonate, and ethanol. The mixture was refluxed for 2 hours followed by addition of tin dichloride while the mixture was maintained at 70° C. After heating overnight the mixture was then cooled and filtered through silica, eluting with 10% CH3OH/CHCl3. The organic layer was then concentrated under vacuum and subjected to purification via Reverse phase (C-18) column chromatography (3% to 100% CH3CN/H2O with 0.1% TFA) to provide the title product.

Provenance & Evidence