HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-(2-Bromophenyl)ethanamine → (S)-{4-[4-[1-(2-Bromo-phenyl)-ethylcarbamoyl]-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-(2-Bromophenyl)ethanamine | HCID 2530257 | — |
| Reactant | 4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid | HCID 59376892 | — |
| Product | (S)-{4-[4-[1-(2-Bromo-phenyl)-ethylcarbamoyl]-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester | HCID 67040357 | 30% |
Reaction Steps
According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and S-(−)-1-(2-bromophenyl)ethylamine (prepared in Example 394B): yield 30%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07910595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-c9bf613aa0b044bd83c1e6ef8193a966 |
| Source note | uspto-grants-2011_03 |