(R)-beta-aminophenethyl alcohol → HCID 67040457, compound

HRID 605344Notes

Reaction equation

HRID 605344 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16]2[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][C:17]=2[NH:25][C:26]2[C:27]3[CH:35]=[CH:34][C:33]([CH:36]([CH3:38])[CH3:37])=[N:32][C:28]=3[N:29]=[CH:30][N:31]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:39]1[CH:44]=[CH:43][C:42]([C@@H:45]([NH2:48])[CH2:46][OH:47])=[CH:41][CH:40]=1>>[C:1]([O:5][C:6](=[O:7])[NH:8][C:9]1[CH:10]=[CH:11][C:12]([S:15][C:16]2[CH:24]=[CH:23][C:19]([C:20](=[O:21])[NH:48][C@H:45]([C:42]3[CH:43]=[CH:44][CH:39]=[CH:40][CH:41]=3)[CH2:46][OH:47])=[CH:18][C:17]=2[NH:25][C:26]2[C:27]3[CH:35]=[CH:34][C:33]([CH:36]([CH3:37])[CH3:38])=[N:32][C:28]=3[N:29]=[CH:30][N:31]=2)=[CH:13][CH:14]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 2724025(R)-beta-aminophenethyl alcoholHCID 593768924-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid

Product 1

HCID 67040457HCID 67040457, compoundYield 70%

Procedure

According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and R-(−)-2-phenylglycinol: yield 70%.

Sources & evidence

ORD record
ord-92d9de70a15e4328b46c3ebac589cc6c
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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