HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-N-allyl-alpha-methylbenzylamine → (S)-{4-[4-[Allyl-(1-phenyl-ethyl)-carbamoyl]-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-N-allyl-alpha-methylbenzylamine | HCID 10899069 | — |
| Reactant | 4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid | HCID 59376892 | — |
| Product | (S)-{4-[4-[Allyl-(1-phenyl-ethyl)-carbamoyl]-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester | HCID 67040641 | 36% |
Reaction Steps
According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and (S)-N-allyl-α-methylbenzylamine: yield 36%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07910595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-36cb9cdb42ff401a9c90029bbdd34801 |
| Source note | uspto-grants-2011_03 |