Ethyl Acetate → 4-(4-Hydroxy-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

Participants

Reaction Conditions

Reaction Steps

A suspension of N′-(3-cyano-6-isopropyl-pyridin-2-yl)-N,N-dimethyl-formamidine (0.75 g, 3.5 mmol) and 3-amino-4-(4-hydroxy-phenylsulfanyl)-benzoic acid methyl ester (0.96 g, 3.5 mmol) in AcOH (15 mL) was heated at 120° C. for 10 minutes under N2. The reaction mixture was portioned between AcOEt (10 mL) and H2O (150 mL) and made basic to pH 9 with K2CO3 under stirring. The resulting solid was collected by filtration, washed with H2O and AcOEt, and dried at 50° C. overnight under reduced pressure to give the title compound as pale brown crystal (1.27 g, 82%).

Provenance & Evidence