1-Phenethylamine, (+)- → HCID 67040869, compound

HRID 605355Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C:9]1[CH:38]=[CH:37][C:12]([O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=2[NH:23][C:24]2[C:25]3[CH:33]=[CH:32][C:31]([CH:34]([CH3:36])[CH3:35])=[N:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:39][C@@H:40]([NH2:47])[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[C:1]([O:5][C:6](=[O:7])[NH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18](=[O:19])[NH:47][C@@H:40]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH3:39])=[CH:16][C:15]=2[NH:23][C:24]2[C:25]3[CH:33]=[CH:32][C:31]([CH:34]([CH3:36])[CH3:35])=[N:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[CH:37][CH:38]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 6431891-Phenethylamine, (+)-

HCID 67040533HCID 67040533, compound

Product 1

HCID 67040869HCID 67040869, compoundYield 84%

Procedure

According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenoxy)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 411D) and R-(+)-α-methylbenzylamine: yield 84%.

Sources & evidence

ORD record: ord-cb426291d39d4579a7cd80ce266fcd3b
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07910595B2

Reaction notes

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