Benzyl 1-(di-tert-butoxyphosphoryloxy)-2-phenylpropan-2-ylcarbamate → 2-Amino-2-phenylpropyl di-tert-butyl phosphate

Participants

Reaction Steps

The product of Example 442B (0.10 g, 0.21 mmol) and 20% palladium hydroxide on carbon (0.02 g) in ethyl acetate (1 mL) and methanol (1 mL) was stirred under an atmosphere of hydrogen or 18 hours. The reaction was filtered through a bed of celite and concentrated to give the title compound, which was used without further purification (0.073 g).

Provenance & Evidence