Sodium borohydride → (S)-2-Amino-2-phenyl-1-propanol

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Reaction Steps

The product of Example 445C (1.28 g, 6.6 mmol, prepared in) was reacted with sodium borohydride (1.25 g, 33 mmol) in 75% aqueous EtOH (32 mL) at reflux for 1 hour. The reaction was concentrated, diluted with water (20 mL) and extracted with ethyl acetate (3×75 mL). The organic layer was washed with 10% NaHCO3 solution (2×10 mL), dried over MgSO4, and concentrated to give the title compound as colorless viscous oil (1.09 g., 100%).

Provenance & Evidence