ethyl (2R)-2-amino-2-phenylpropanoate → (R)-2-Amino-2-phenylpropan-1-ol

Participants

Reaction Steps

The title compound was prepared by the procedure of Example 445D substituting the product of Example 450B for the product of Example 445C to give a colorless viscous oil (0.57 g, 67%). [α]D23: −13.8°(c=1.05, EtOH). 1H-NMR (300 MHz, DMSO-d6) δ ppm: 1.28 (s, 3H), 1.76 (br-s, 2H), 3.39 (d, J=5.2 Hz, 2H), 4.72 (t, J=5.2 Hz, 1H), 7.12-7.20 (m, 1H), 7.22-7.32 (m, 2H), 7.44-7.54 (m, 2H). MS ESI+ m/z: 152 (M+H).

Provenance & Evidence