HCID 66808370, compound → HCID 60204801, compound

Participants

Reaction Steps

The product from Example 458D was reacted with the product from Example 9B using the procedure described in Example 458E substituting the product from Example 9B for the product from Example 8E to provide {4-[4-(4-Bromo-phenylsulfamoyl)-2-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester which was deprotected according to the procedure described in Example 458F, followed by silica gel chromatography provided the title compound as a trifluoroacetic acid salt. 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.74 (s, 3 H), 6.64 (d, J=8.46 Hz, 2 H), 6.89 (d, J=8.09 Hz, 1 H), 7.05 (d, J=9.19 Hz, 2 H), 7.12 (d, J=8.82 Hz, 2 H), 7.44 (d, J=8.82 Hz, 2 H), 7.63 (dd, J=7.72, 0.74 Hz, 1 H), 7.74 (s, 1 H), 7.79 (dd, J=7.72, 1.10 Hz, 1 H), 8.70-8.83 (m, 1 H), 8.88 (d, J=8.09 Hz, 1 H), 10.55 (s, 1 H); MS (ESI+) m/z 593/595 (M+H)+.

Provenance & Evidence