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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 605541Generated: October 25, 2026

4-Bromo-3-fluorobenzotrifluoride → 1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine

https://huagongshe.com/reaction/605541

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-3-fluorobenzotrifluorideHCID 142414—
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Product1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazineHCID 46837495—

Reaction Steps

The compound 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine is synthesized according to the procedure outlined in Example 26 steps 1 and 2 using t-butyl-1-piperazine-carboxylate and 1-bromo-2-fluoro-4-trifluoromethyl-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07915253B2
Source datasetuspto-grants-2011_03
ORD IDord-5a157c6622a640bca9be076b58cea00e
Source noteuspto-grants-2011_03