2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 86635795, compound

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Reaction Steps

A mixture of 0.45 g of the compound obtained in stage A of Example 18, 0.38 g of 2,2,2-trifluoroethyltrifluoromethanesulfonate and 0.28 g of NaHCO3 in 14 ml of EtOH is refluxed for 2 hours. The reaction mixture is concentrated under vacuum, the residue is taken up with water, the mixture is extracted with DCM, the organic phase is dried over Na2SO4, and the solvent is evaporated off under vacuum. The residue is chromatographed on silica gel, elution being carried out with a mixture of DCM/EtOAc (100/30; V/V). 0.145 g of the expected compound is obtained after crystallization from iso ether.

Provenance & Evidence