HCID 16110608, compound → HCID 16110640, compound

Participants

Reaction Steps

The title compound was prepared from 3-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)phenol (29 mg, 0.062 mmol) following General Procedure D. Preparative thin layer chromatography (30% EtOAc) yielded the title compound as a white solid (5.2 mg, 27%): 1H NMR (CD3OD, 500 MHz) δ 7.74 (s, 1H), 7.38-7.37 (m, 2H), 7.32-7.29 (m, 3H), 7.24-7.23 (m, 2H), 7.21-7.20 (m, 1H), 6.95-6.94 (m, 1H), 3.14 (t, 2H, J=7.0 Hz), 2.69 (t, 2H, J=7.5 Hz), 1.85-1.79 (m, 2H), 1.75-1.69 (m, 2H), 1.54-1.42 (m, 4H); 13C NMR (CD3OD, 125 MHz) δ 188.5, 158.4, 157.4, 154.7, 142.9, 130.5, 128.4, 128.2, 128.2, 125.6, 123.9, 117.2, 116.5, 111.7, 38.7, 35.8, 31.5, 29.0, 29.0, 23.9; MALDI-FTMS m/z 350.1752 (M+H+, C22H24NO3, requires 350.1751).

Provenance & Evidence