HCID 16110686, compound → HCID 16110712, compound

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Reaction Steps

The title compound was prepared from methyl 2-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)nicotinate (30 mg, 0.059 mmol) following General Procedure C. Flash chromatography (10-30% EtOAc) yielded the title compound as a white solid (17 mg, 73%): 1H NMR (CDCl3, 500 MHz) δ 8.85-8.84 (m, 1H), 8.10 (dd, 1H, J=8.0, 1.5 Hz), 7.94 (s, 1H), 7.49-7.47 (m, 1H), 7.36-7.33 (m, 2H), 7.26-7.25 (m, 3H), 4.07 (s, 3H), 3.17 (t, 2H, J=7.0 Hz), 2.69 (t, 2H, J=7.5 Hz), 1.88-1.82 (m, 2H), 1.75-1.69 (m, 2H), 1.53-1.47 (m, 4H); 13C NMR (CDCl3, 125 MHz) δ 188.5, 167.6, 152.3, 151.8, 144.3, 143.1, 137.7, 129.5, 128.8, 128.7, 127.5, 126.0, 123.9, 53.7, 39.5, 36.3, 31.7, 29.4, 29.4, 24.2; MALDI-FTMS m/z 393.1799 (M+H+, C23H25N2O4, requires 393.1809).

Provenance & Evidence