HCID 16110713, compound → HCID 16110658, compound

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Reaction Steps

The title compound was prepared from methyl 6-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinate (10 mg, 0.025 mmol) following General Procedure E. Preparative thin layer chromatography (2% AcOH/EtOAc) yielded the title compound as a white solid (4 mg, 40%): 1H NMR (THF-d8, 500 MHz) δ 9.18 (s, 1H), 8.41 (d, 1H, J=8.0 Hz), 7.97-7.94 (m, 2H), 7.22-7.09 (m, 5H), 3.08 (t, 2H, J=7.5 Hz), 2.61 (t, 2H, J=7.5 Hz), 1.74-1.69 (m, 2H), 1.67-1.61 (m, 2H), 1.47-1.40 (m, 4H); 13C NMR (THF-d8, 125 MHz) δ 185.6, 163.6, 156.7, 151.1, 149.8, 147.9, 141.0, 136.7, 126.7, 126.5, 125.0, 123.9, 117.7, 37.2, 34.3, 29.9, 27.6, 27.5, 22.2; MALDI-FTMS m/z 379.1645 (M+H+, C22H23N2O4, requires 379.1652).

Provenance & Evidence