HCID 16110712, compound → HCID 16110657, compound

Participants

Reaction Steps

The title compound was prepared from methyl 2-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinate (8 mg, 0.020 mmol) following General Procedure E. Preparative thin layer chromatography (2% AcOH/EtOAc) yielded the title compound as a white solid (3 mg, 38%): 1H NMR (THF-d8, 600 MHz) δ 8.71 (d, 1H, J=4.8 Hz), 8.09 (d, 1H, J=7.8 Hz), 7.79 (s, 1H), 7.45-7.44 (m, 2H), 7.22-7.19 (m, 2H), 7.16-7.14 (m, 2H), 7.11-7.08 (m, 1H), 3.05 (t, 2H, J=7.8 Hz), 2.60 (t, 2H, J=7.2 Hz), 1.73-1.69 (m, 2H), 1.66-1.61 (m, 2H), 1.43-1.39 (m, 4H); 13C NMR (THF-d8, 150 MHz) δ 185.5, 165.6, 156.4, 150.9, 149.5, 142.7, 141.1, 135.7, 127.0, 126.7, 126.5, 125.9, 123.9, 121.9, 37.1, 24.3, 30.0, 27.6, 27.5, 22.2; MALDI-FTMS m/z 379.1646 (M+H+, C22H23N2O4, requires 379.1652).

Provenance & Evidence