HCID 57507786, compound → HCID 57507787, compound

HRID 605817Notes

Reaction equation

HRID 605817 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[O:19])[CH2:14][CH2:13]1)=O>C(O)(=O)C>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:9]=[C:10]1[CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[O:19])[CH2:14][CH2:13]1

Participants

3

Reactant 1

HCID 57507786HCID 57507786, compound

Product 1

HCID 57507787HCID 57507787, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Pyridin-3-yl 4-({[2-(methylamino)phenyl]amino}carbonyl)piperidine-1-carboxylate (0.41 g) was dissolved in acetic acid (10 ml), followed by heating under reflux for 2 hours. The solvent was evaporated, and the residue was recrystallized from methanol and diethyl ether to obtain (pyridin-3-yl) 4-(1-methyl-1H-benzimidazol-2-yl)piperidine-1-carboxylate (307 mg).

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 2 hours
  3. customThe solvent was evaporated
  4. customthe residue was recrystallized from methanol and diethyl ether

Sources & evidence

ORD record
ord-c0648b01517a4d4f822203f2c720ee57
Source dataset
uspto-grants-2011_03
Patent number
US07915261B2

Reaction notes

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