反应详情

温度

-78 °C

8-Fluoro-4-methylene-3,4-dihydro-1H-isochromene (400 mg) was dissolved in a solution of 1:1 MeOH/DCM (50 mL) and 1 mL of pyridine added. The mixture was chilled to −78° C. and ozone was bubbled through the mixture for 40 min. The reaction monitored by TLC. The mixture was purged with nitrogen at −78° C. for 10 min and then treated with PPh3. After concentration, the resulting residue was purified by preparative TLC to offer 300 mg of the title compound.

1. additionadded
2. customozone was bubbled through the mixture for 40 min
3. customThe mixture was purged with nitrogen at −78° C. for 10 min
4. additiontreated with PPh3
5. concentrationAfter concentration
6. customthe resulting residue was purified by preparative TLC