8-Fluorochroman-4-amine → 8-Fluoroisochroman-4-amine

HRID 605848Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][O:9][CH2:8][C:7]2=O.FC1C=CC=C2C=1OCCC2[NH2:24]>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][O:9][CH2:8][CH:7]2[NH2:24]

Participants

Reactant 2

HCID 162444038-Fluorochroman-4-amine

HCID 534239858-Fluoroisochroman-4-one

Product 1

HCID 597050428-Fluoroisochroman-4-amine

Procedure

The title compound was prepared from 8-fluoro-1H-isochromen-4(3H)-one via the procedure described above for the synthesis of 8-fluorochroman-4-amine.

Sources & evidence

ORD record: ord-9f1552bc7a23457ea6cc169eb48adb84
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07915268B2

Reaction notes

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