Trityl chloride → HCID 178521610, compound

Participants

Reaction Steps

Trans-4-aminocyclohexanol (2.6 g, 22.6 mmol) was suspended in 60 mL DCM, then 4 mL (28.7 mmol) triethylamine was added. The mixture was cooled in ice bath, and trityl chloride (6.3 g, 22.6 mmol) was added. The mixture was stirred overnight, allowing it to slowly warm up. Saturated NaHCO3 was added to quench the chloride, and product was extracted with EtOAc three times. The combined organic layer was washed with brine, and dried over Na2SO4. Column chromatography with 20-40% EtOAc in hexanes provided 5.3 g (66%) white solid.

Provenance & Evidence