HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetic Acid → HCID 59704975, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetic Acid | HCID 999 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 59704965 | HCID 59704965 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 59704975 | HCID 59704975 | 75% |
Reaction Steps
To the solution of 10 mg (0.030 mmol) 2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-N4-(tetrahydro-2H-pyran-4-yl) pyrimidine-4,5-diamine in 1 mL acetonitrile was added 16 mg (0.12 mmol) of phenylacetic acid and 20 mg (excess) 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride. The solution was stirred for 1 hr at room temperature. Solvent was removed under vacuum and column chromatography with 5% MeOH in DCM provided 10 mg (75%) pale yellow solid as the desired amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915268B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-bba532b8269d43fdae06c9b00819fdd6 |
| Source note | uspto-grants-2011_03 |