反应详情

To a cooled (0° C.) solution of 2-morpholin-4-yl-5-nitro-benzaldehyde (0.8 g, 3.39 mmol) in MeOH (5 mL) is added NaBH4 (0.125 g, 3.39 mmol) and the reaction mixture is stirred at room temperature for 3 hours. After quenching the reaction with water, the solvent is removed in vacuo and the residue dissolved in ethyl acetate and washed with brine. The organic layer is dried over MgSO4, filtered and concentrated to afford the title compound (870 mg), which is used in the next step without further purification.

1. customAfter quenching
2. customthe reaction with water
3. customthe solvent is removed in vacuo
4. dissolutionthe residue dissolved in ethyl acetate
5. washwashed with brine
6. dry with materialThe organic layer is dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated