(5-Carbamoylthiophen-3-yl)boronic acid → 4-{8-[4-(4-(Cyclopropylmethyl)piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}thiophene-2-carboxylic acid amide

Participants

Role	Name	HCID	Charge
Reactant	(5-Carbamoylthiophen-3-yl)boronic acid	HCID 67047388	—
Reactant	{4-[4-(Cyclopropylmethyl)piperazin-1-yl]phenyl}-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine	HCID 135900377	—
Product	4-{8-[4-(4-(Cyclopropylmethyl)piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}thiophene-2-carboxylic acid amide	HCID 24888611	—

Reaction Steps

This compound may be prepared using methods as described for Compound 46, using 2-(aminocarbonyl)thiophene-4-boronic acid. LCMS: Rt=0.93 (95%), m/z (ESI) 475 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07915256B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-819a7f3d0c234849bc03f419f6138704
Source note	uspto-grants-2011_03