(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-cyclopropylpiperazin-1-yl)-phenyl]amine → [4-(4-Cyclopropylpiperazin-1-yl)phenyl]-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine

HRID 605933Notes

Reaction equation

HRID 605933 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:18]4[C:19]5[N:20]([N:29]=[CH:30][N:31]=5)[C:21]([C:24]5[CH:25]=[N:26][NH:27][CH:28]=5)=[CH:22][N:23]=4)=[CH:13][CH:12]=3)[CH2:7][CH2:6]2)[CH2:3]C1.BrC1N2N=CN=C2C(NC2C=CC(N3CCN(C4CC4)CC3)=CC=2)=NC=1>>[CH:4]1([N:5]2[CH2:6][CH2:7][N:8]([C:11]3[CH:12]=[CH:13][C:14]([NH:17][C:18]4[C:19]5[N:20]([N:29]=[CH:30][N:31]=5)[C:21]([C:24]5[CH:25]=[N:26][NH:27][CH:28]=5)=[CH:22][N:23]=4)=[CH:15][CH:16]=3)[CH2:9][CH2:10]2)[CH2:1][CH2:3]1

Participants

3

Reactant 2

HCID 86619663(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-cyclopropylpiperazin-1-yl)-phenyl]amineHCID 135900377{4-[4-(Cyclopropylmethyl)piperazin-1-yl]phenyl}-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine

Product 1

HCID 135900350[4-(4-Cyclopropylpiperazin-1-yl)phenyl]-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine

Procedure

This compound may be prepared using methods as described for Compound 46, using (5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-cyclopropylpiperazin-1-yl)-phenyl]amine. LCMS: Rt=0.84 (95%), m/z (ESI) 402 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-86a00fb726b84e12a122d99853619c35
Source dataset
uspto-grants-2011_03
Patent number
US07915256B2

Reaction notes

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