Diethyl Carbonate → Ethyl 4-bromothiazole-2-carboxylate

Temperatur

0 °C

To a solution of dibromothiazole (1 g, 4.15 mmol) in THF (15 mL) at 0° C., is added dropwise a solution of iPrMgCl in THF (2 M, 2.3 mL, 4.57 mmol, 1.10 equiv.). The reaction is stirred at 0° C. for 0.25 h. To the resulting orange solution is added via a cannula, diethyl carbonate (3 mL) in THF (5 ml). The resulting green solution is stirred further at room temperature for 0.5 h, at which point the reaction is quenched by adding saturated NH4Cl. The title compound is purified by LC using 6/4 cyclohexane/DCM as the eluent to afford 514.2 mg (52%) of the title compound as a pale yellow powdery solid.

1. stirringThe resulting green solution is stirred further at room temperature for 0.5 h, at which
2. customis quenched
3. additionby adding saturated NH4Cl
4. customThe title compound is purified by LC

ORD-Eintrag

ord-1842841737b94662a73ef1c8b5129fd1

Quelldatensatz

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07915256B2